DNA drives autoimmunity

From hard drives to flash drives to DNA drives.

Recently there has been another round of controversial news regarding genetically modified organisms (GMO). Perhaps the best known debate on these centers on corn. A recent French study showed severe kidney and liver abnormalities in rats that were fed this corn for up to 2 years. Immediately afterward, Russia banned the use of this seed and the corn it produces. Because other studies have not ...

The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity.

Rheumatoid arthritis (RA) is a chronic and debilitating inflammatory autoimmune disease of unknown etiology. As with a variety of autoimmune disorders, evidence of elevated tryptophan catabolism has been detected in RA patients indicative of activation of the immunomodulatory enzyme IDO. However, the role that IDO plays in the disease process is not well understood. The conceptualization that I...

Antigen-based immunotherapy drives the precocious development of autoimmunity.

During the development of type I diabetes mellitus in nonobese diabetic (NOD) mice, T cell autoimmunity gradually spreads among beta cell Ags. Little is known about how autoantigen-based immunotherapies affect this spreading hierarchy. We treated newborn NOD mice with different autoantigenic beta cell peptides (in adjuvant) and characterized their T cell responses at 4 wk of age, when autoimmun...

Precocious Development of Autoimmunity Antigen-Based Immunotherapy Drives the

Demethylation Drives Estrogen - Induced Gene DNA Oxidation

www.sciencemag.org (this information is current as of January 13, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/319/5860/202 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/319/5860/202/DC1 can be foun...